What are the 4 dengue serotypes? - Study enthusiast (2023)

Dengue serotypes Dengue infections are caused by four closely related viruses called DEN-1, DEN-2, DEN-3, and DEN-4. These four viruses are called serotypes because each has different interactions with antibodies in human blood serum.

How many serotypes of the dengue virus are there?

The virus responsible for causing dengue fever is called dengue virus (DENV). There are four DENV serotypes, which means that it is possible to be infected four times. Although many DENV infections cause only mild illness, DENV can cause an acute flu-like illness.

What is the difference between dengue virus serotypes?

The difference is based on antibody reactions to virus surface antigens. Each serotype has subtle differences in its surface proteins, which means that different antibodies are produced to bind to these proteins. I have attached a decent review on dengue fever.

What is dengue serotype 2?

Dengue serotype 2 (DEN-2) viruses with the potential to cause dengue hemorrhagic fever have been shown to belong to the Southeast Asian (SE) genotype. These viruses appear to be rapidly replacing the American DEN-2 genotype in the Western Hemisphere.

What are the virus serotypes?

A serotype or serovar is a distinct variation within a species of bacteria or virus or between immune cells from different individuals. These microorganisms, viruses, or cells are classified together based on their surface antigens, allowing for the epidemiological classification of organisms at the subspecies level.

Which dengue serotype is the most common?

Serotyping revealed that DENV-1 was the most common form (41%), followed by DENV-2 (31%), DENV-3 (20%) and DENV-4 (7%) [15].

How are dengue serotypes present in India?

Dengue viruses (DV) belong to the Flaviviridae family and there are four virus serotypes called DV-1, DV-2, DV-3 and DV-4.

How is the dengue serotype determined?

Dengue was confirmed and serotyped by real-time reverse transcription polymerase chain reaction (RT-PCR) using an in-house protocol using samples from the first day of presentation.

Can you get dengue twice?

Yes, dengue fever can attack you repeatedly. You can be infected with dengue not once, twice, but several times, and each subsequent infection is deadlier than the previous ones.

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Why are platelets low in dengue?

When an infected mosquito bites a human, the dengue virus enters the bloodstream, attaches to platelets and replicates, leading to the multiplication of the infectious virus. Infected platelet cells tend to destroy normal platelets, which is one of the main causes of low platelet count in dengue.

Is dengue localized or systemic?

DENV infection is a systemic and dynamic disease with a broad clinical spectrum. Gross pathological findings in cases of DHF or DSS include hemorrhages in the skin, subcutaneous tissues, gastrointestinal tract and heart (129).

Is DENV 1 the most common dengue virus?

DENV-1 is one of four viral serotypes that cause dengue, the most common mosquito-borne viral disease in humans.

Why is secondary dengue infection worse?

People who are reinfected with a different type of dengue virus may experience something called an antibody-dependent rise. This condition occurs when the immune response actually worsens the clinical symptoms of dengue, increasing the risk of severe dengue.

How much platelet count is normal in dengue?

A normal person has a platelet count between 150,000 and 250,000 per microliter of blood. About 80 to 90 percent of dengue patients will have levels below 100,000, while 10 to 20 percent of patients will have critically low levels of 20,000 or less.

What is the full form of Den 1?

Dengue virus type 1 (DEN1) vaccine candidates generated by replacing the structural genes of rDEN4 and rDEN4Δ30 with those of DEN1.

What is serotype and genotype?

As nouns, the difference between serotype and genotype is that serotype is a group of microorganisms characterized by a specific set of antigens, whereas genotype is the genotype.

What is serotype replacement?

Serotype replacement refers to the spread of non-vaccine serotypes as a result of elimination from the population of vaccine types that compete with them to colonize new hosts. The main replacement serotypes in the transport studies described here to date have been serotypes 6A, 19A, and 15B/C.

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What is biotype and serotype?

We learned that a serotype is a serologically and antigenically distinct variety of microorganism, such as a subgroup of a species of bacteria. … And finally, we learned that a biotype is a strain, which is distinguished from other microorganisms of the same species, by its physiological properties.

Is dengue for the second time always fatal?

“There are four different serotypes (which can be understood as “types”) of dengue. Therefore, if you were infected by the first serotype, it is equally possible that you will be infected by the second, third and fourth. Only you will be immune for life against the first serotype."

Which dengue serotype is most common in India?

Dengue virus serotypes were tested in 4963 specimens collected in India in 2018. DENV-2 was the most prevalent serotype in many Indian states. Two DENV-1 genotypes (I and V) were circulating. Two DENV-2 genotype IV strains were circulating.

Can you get dengue for the third time?

After you recover from dengue, you have long-term immunity against the type of virus that infected you, but not against the other three types of dengue virus. This means that you could be infected again in the future with one of the other three types of viruses.

How many types of dengue are there in India?

There are four distinct serotypes of dengue virus that are antigenically related: DENV-1, DENV-2, DENV-3 and DENV-4. Each serotype has several subtypes or genotypes. DENV-1 has three, DENV-2 has two, and DENV-3 and DENV-4 each have four.

In which season is dengue most common?

Dengue occurs most frequently in India from July to October, as this season offers highly suitable conditions for mosquitoes to breed.

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Where is dengue most common in India?

Dengue Outbreak: From Uttar Pradesh to MP, the viral fever wreaks havoc across India. Several states in the country are dealing with a dengue outbreak. However, Uttar Pradesh is the state most affected by dengue.

What does serotype mean?

Serotype: The type of organism characterized by serological typing (testing for recognizable antigens on the surface of the organism).

What type of mosquito transmits dengue?

Aedes aegypti mosquito. Dengue viruses are transmitted to people through the bite of infected mosquitoes of the Aedes species (Ae. aegypti or Ae. albopictus).

Can you be immune to dengue?

Recovery from dengue virus infection provides lifelong immunity against this specific serotype of the virus. However, this immunity confers only partial and transient protection against subsequent infection by the other three serotypes of the virus.

How can we build immunity against dengue fever?

Preventing Dengue: Foods That Boost Immunity

  1. citrus foods. Citrus foods are rich in vitamin C, which helps build strong immunity. …
  2. Garlic. Garlic gives a strong flavor to food. …
  3. Yogurt. Yogurt is a strong probiotic that boosts the immune system. …
  4. Spinach. …
  5. almonds. …
  6. Turmeric. …
  7. Red-haired.

What happens if you get dengue 3 times?

A patient can contract dengue from two or more different dengue strains. Thus, a patient may suffer from dengue more than once. When dengue strikes twice: When patients are infected with the dengue virus, they can contract dengue hemorrhagic fever and experience massive internal bleeding and liver damage.

What are the 4 dengue serotypes? - Study enthusiast (1)

Perrine Julilhao

Graduated from ENSAT (Toulouse national school of agronomy) in plant sciences in 2018, I did a CIFRE PhD under contract with Sun'Agri and INRAE ​​​​​​​​​​in Avignon between 2019 and 2022. My thesis aimed to study systems dynamic agrovoltaics, in my case in arboriculture. I love writing and sharing science related stuff here on my website. Currently I continue at Sun'Agri as an R&D engineer.

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